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苯妥林(AKA Dilantin或二苯基氢素)

Phenytoin是最广泛规定的抗惊厥药之一。它也偶尔使用作为心肌抗心律失常。测量苯基水平以确保维持适当的治疗水平。由于治疗指数狭窄,加上苯妥英代谢和清除率的广泛个性变异,治疗药物监测在用苯妥林治疗期间必不可少。水平不足可能导致症状管理不足,而过度水平会导致危险的毒性。BC癌症机构的患者可能会接受各种症状的苯妥林治疗。因此,肿瘤标志物实验室衡量苯妥汀作为其测试菜单的一部分。在Abbott TDX分析仪上使用荧光偏振免疫测定(FPIA)测量苯妥汀。样品是血清,仅在红色顶部(无添加剂)管中收集。SST管可能导致治疗药物检测干扰。 Testing is performed STAT. Samples are to be sent immediately to the lab. The requisition is to include the diagnosis, sample date, and sample time. Turnaround time is 90 minutes after receipt in the TML. Please provide a contact number so results may be phoned to the correct physician or location. Therapeutic Range = 40-80 umol/L Interferences: Some cross reactivity with Fosphenytoin. However, this is not an issue if patient samples are drawn at least two hours post IV administration or 4 hours post IM administration. Uremic specimens may exhibit a positive bias with the phenytoin assay.

来源:Phenytoin(AKA Dilantin或二苯基氢丁蛋白)(
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